Endothelial cell proliferation as a novel approach to targeting tumour therapy
نویسندگان
چکیده
منابع مشابه
O15: Using Stromal Cell-Derived Factor-I as Bio Active Motif in A Novel Self-Assembly Peptide Nanofiber Scaffold: an Approach to Improve Cell Therapy in Brain Injury
Traumatic brain injury (TBI) is one of the main causes of mortality and morbidity worldwide. Despite extensive investigations over the past few decades, no effective therapies exist to improve the brain function in patients with TBI. Neural tissue engineering is an attractive therapeutic approach to restore the brain structure and function of damaged tissue. Bioactive motif of Stromal cell-deri...
متن کاملTargeting of AUF1 to vascular endothelial cells as a novel anti-aging therapy
BACKGROUND Inhibition of aging of vascular endothelial cells (VECs) may delay aging and prolong life. The goal of this study was to prepare anti-CD31 monoclonal antibody conjugated PEG-modified liposomes containing the AU-rich region connecting factor 1 (AUF1) gene (CD31-PILs-AUF1) and to explore the effects of targeting CD31-PILs-AUF1 to aging VECs. METHODS The mean particle sizes of various...
متن کاملDalteparin as a Novel Therapeutic Agent to Prevent Diabetic Encephalopathy by Targeting Oxidative Stress and Inflammation
Introduction: Hepcidin is the principal modulator of systemic iron metabolism, and its role in the brain has been clarified recently. Studies have shown hepcidin plays an important role for in neuronal iron load and inflammation. This is of significance because neuronal iron load and inflammation are pathophysiological processes that have been highly linked to neurodegeneration. Moreover, the a...
متن کاملChemoimmunotherapy as a Novel Cancer Therapy
Over the past decade, it was widely accepted that some chemotherapeutic drugs can be combined with immunotherapeutic drugs in treatment of cancer. Chemotherapeutic drugs can induce apoptosis in the tumor cell and at the same time stimulate the immune response. Several reports support the use immunomodulators in treatment of cancers through regulating the immune response and boosting the micro...
متن کاملIAP antagonism as a novel approach to target endothelial activation
Endothelial barrier dysfunction is a hallmark of many severe pathologies including sepsis or atherosclerosis. The cardiovascular hormone atrial natriuretic peptide (ANP) has increasingly been suggested to counteract endothelial leakage. Surprisingly, the precise in vivo relevance of these observations has never been evaluated. Thus, we aimed to clarify this issue and, moreover, to identify the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1982
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1982.16